Sarojini was a bright child who passed her matriculation at the age of 12 standing first in the Madras Presidency. She studied at the King's college, London and Girton College, Cambridge for a while. During this period her creative urge found expression in poems. She also happened to be a good singer. Her ability to sing charmingly fetched her the title 'Nightingale of India'. After 1917 she stepped into active politics. In 1898 she married Dr. Govindarajulu Naidu.
Sarojini actively campaigned for the Montagu-Chelmsford Reforms, the Khilafat issue, the Rowlatt Act, the Sabarmati Pact, the Satyagraha Pledge and the Civil Disobedience Movement.
In 1919, she went to England as a member of the all-India Home Rule Deputation. After 1920 she toured widely as the President of the Bombay Provincial Congress Committee opposed Council entry in Calcutta and protested against the anti-Moplah measures in Calicut.
She was the first woman Governor of UP. Her Presidentship of the Asian Relations Conference in 1947 was remarkable. At the age of seventy on 02 March 1949 she died in office at Lucknow.